Monday, May 27th, 2019

Scientists Have Made Artificial Sperm, and They Used It to Fertilize Eggs

Published on February 29, 2016 by   ·   No Comments

Scientists from Nanjing Medical University in China managed to create artificial sperm, and it has been used to successfully fertilize mouse eggs and produced healthy offsprings.

They used embryonic stem cell to grow what is now dubbed as the “most effective test tube sperm cells ever.” Their artificial sperm is the first in the world to meet a set of criteria that was established by three fertility researchers in 2014, earning them the “gold standards” for proof of meiosis.

The results of their study have been published in Cell Stem Cell.

“The achievements of this paper are very remarkable,” John Schimenti of Cornell University, one of the researchers who defined the gold standard, told New Scientist. “I’m not aware of another group having progressed this far.”

The team of scientists created artificial spermatids, which are actually immature versions of sperm cells, meaning they have no tails yet. Due to their inability to swim, these sperms are injected into a mouse egg via IVF.

The researchers harvested embryonic stem cells from mice and put them in chemicals called cytokines, which then transforms them into germ cells. Germ cells are a type of cell that gives rise to sex cells like eggs or sperm. While the cells were differentiating, they were placed next to testes-like tissue and exposed to the male sex hormone, testosterone, to coax them into a spermatid form.

To prove the effectivity of these cells, the team had to show that these cells retain important characteristics, such as having the right number of chromosomes and the right percentage of donor DNA. That may sound easy, but a lot of failed attempts occurred when trying to control all the key stages of sex cell division.

Read More HERE

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